Abstract
Current laboratory methods do not provide an adequate guide for determination of the chemotherapeutic efficacy of antimycotic agents. Any one of a number of different in vitro fungistatic and fungicidal tests similar to those which Reddish (1) describes may be used to establish antifungal activity, but practically none takes into account the limited penetrability of the stratum corneum. For this reason, many potent antifungal agents are not clinically useful because they fail to reach the infecting organism within the horny layer. Addition of lipids, keratin, and plasma protein to the test medium does not correct this deficiency, since the infecting organism may be embedded in a combination of these components of damaged skin.
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