Abstract
A self-powered biosensing system based on triboelectric nanogenerator (TENG) for bacterial DNA detection is invented and a vertical contact-separation TENG was designed to provide a steady power supply to a detection bioreactor. A carboxyl-functionalized capture probe was modified on etched indium tin oxide (ITO) glass, with which target bacterial DNA could be recognized. Meanwhile, multi-walled carbon-nanotubes (CNT)-modified signal probe was designed to amplify the detection signal due to its excellent electrical conductivity. The self-powered biosensing system could measure the variation in output voltage and be highly sensible with a low detection limit at 0.084 pM of target DNA. In addition, a mathematical model based on the Freundlich isotherm was built to simulate the DNA detection process, and it was feasible to simulate the calibration equation and detection range. A portable self-powered biosensing device was made by integrating miniaturized TENG and bioreactor in a 3D-printed mold, with which the presence of bacterial DNA could be instantly indicated by LED (light-emitting diode). This study provided a useful platform for quick bacterial DNA detection and paved the way for further development of pocket diagnosis with TENG-based biosensing systems.
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