Abstract
The plasmonic optical fiber sensors have attracted wide attention for label-free biosensing application because of their high integration, small footprint and point-of-care measurement. However, the integration of plasmonic nanostructures on optical fiber probes always relies on the top-down nanofabrication approaches, which have several inherent shortcomings, including high cost, time-consuming, and low yields. Here, we develop a plasmonic nanohole-patterned multimode optical fiber probe by self-assembly nanosphere lithography technique with low fabrication cost and high yields. The multimode optical fiber possesses large facet area and high numerical aperture, which not only simplifies fabrication process, but also increases coupling efficiency of incident light. Originating from the resonant coupling of plasmonic modes, the plasmonic fiber nanoprobe has a distinct reflection dip in the spectrum and exhibits strong near-field electromagnetic enhancement. We experimentally investigate the sensing performances of plasmonic fiber nanoprobe, and further demonstrate it in real-time monitoring specific binding of protein molecules. The experimental results imply that the nanohole-patterned multimode optical fiber probe is a good candidate for developing miniaturized and portable biosensing systems.
Highlights
Plasmonic nanostructure sensors, as a powerful analytical tool, have great application potentials in the fields of clinical diagnosis, drug development, and healthcare monitoring[1,2,3,4,5,6,7,8,9,10]
Several nanofabrication technologies established for planar substrates have been employed for the integration of plasmonic nanostructures on optical fiber tip, including electron beam lithography (EBL)[16,17,18], focused ion beam (FIB) milling[19,20,21], nanoimprint lithography[22,23], and template transfer[24,25,26]
In this paper, based on self-assembly nanosphere lithography approach combined with plasmon etching, we develop a miniaturized and portable biosensing platform
Summary
As a powerful analytical tool, have great application potentials in the fields of clinical diagnosis, drug development, and healthcare monitoring[1,2,3,4,5,6,7,8,9,10]. Several nanofabrication technologies established for planar substrates have been employed for the integration of plasmonic nanostructures on optical fiber tip, including electron beam lithography (EBL)[16,17,18], focused ion beam (FIB) milling[19,20,21], nanoimprint lithography[22,23], and template transfer[24,25,26] These top-down technologies suffer from several inherent shortcomings, such as high equipment cost, time-consuming and low yields. To overcome these drawbacks, nanosphere lithography technique, with unique features of rapid and large-scale preparation of ordered nanostructure array, is recently used to fabricate the nano-patterned fiber probe[27,28]. Due to high surface sensitivity, specific binding of protein molecules is experimentally monitored in real-time by plasmonic fiber nanoprobe
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
