A second successful pregnancy using oocytes from a woman with premature ovarian failure with embryos transferred to a gestational carrier

Abstract

Purpose: To describe a second successful pregnancy in a woman with premature ovarian failure who was successfully able to induce ovulation by restoring down-regulated follicle stimulating hormone (FSH) receptors, by lowering elevated FSH by inhibiting FSH release from the pituitary, by using ethinyl estradiol with subsequent stockpiling of embryos following in vitro fertilization (IVF) for subsequent future transfer to a gestational carrier. Materials and Methods: A day 3 eight-cell embryo obtained from a fertilized oocyte 10.5 years before was transferred to a gestational carrier. Results: The gestational carrier conceived and she successfully carried to six months to date. Conclusions: This is the first case of two successful pregnancies from the same woman with premature ovarian failure. Also, this is the longest an embryo derived from a woman in ovarian failure has been frozen leading to a successful pregnancy.