Abstract
Gentamicin was administered s.c. to rats once daily for 7 days at 5 mg kg-1. At the end of this period renal concentrations of gentamicin declined from day 1 to day 5 postdosing, but showed a second peak on day 8, after which they declined again through days 16 and 22. This second peak coincided with a peak of mitotic activity in the kidney, suggesting that this organ, while recovering from gentamicin-induced damage, passes through a temporary phase during which it has increased affinity for gentamicin.
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