A second order accurate approximation for fractional derivatives with singular and non-singular kernel applied to a HIV model

Abstract

In this manuscript we examine the CD4+ T cells model of HIV infection under the consideration of two different fractional differentiation operators namely Caputo and Caputo-Fabrizio (CF). Moreover, the generalized HIV model is investigated by considering Reverse Transcriptase (RT) inhibitors as a drug treatment for HIV. The threshold values for the stability of the equilibrium point belonging to non-infected case are calculated for both models with and without treatment. For the numerical solutions of the studied model, we construct trapezoidal approximation schemes having second order accuracy for the approximation of fractional operators with singular and non-singular kernel. The stability and convergence of the proposed schemes are analyzed analytically. To illustrate the dynamics given by these two fractional operators, we perform numerical simulations of the HIV model for different biological scenarios with and without drug concentration. The studied biological cases are identified by considering different values of the parameters such as infection rate, growth rate of CD4+ T cells, clearance rate of virus particles and also the order of the fractional derivative.