Abstract
Autologous chondrocyte implantation (ACI) is the most widely used cell-based surgical procedure for the repair of articular cartilage defects. Challenges to successful ACI outcomes include limitation in defect size and geometry as well as inefficient cell retention. Second-generation ACI procedures have thus focused on developing three-dimensional constructs using native and synthetic biomaterials. Clinically significant and satisfactory results from applying autologous chondrocytes seeded in fibrin within a biodegradable polymeric material were recently reported. In the future, third-generation cell-based articular cartilage repair should focus on the use of chondroprogenitor cells and biofunctionalized biomaterials for more extensive and permanent repair.
Highlights
The hyaline articular cartilage protects the bones of diarthrodial joints from forces associated with load bearing, friction, and impact
Chondroprogenitor cells derived from the bone marrow migrate to the lesion and initiate a repair process that results in the formation of a fibrocartilage repair tissue [1,2]
The Autologous chondrocyte implantation (ACI) procedure involves the use of a periosteal flap or a collagen sheet [12], which is fixed to the surrounding cartilage to create a reservoir for injection of a suspension of culture-expanded autologous chondrocytes
Summary
Abstract to promote a natural fibrocartilaginous response by using marrow stimulating techniques, such as abrasion arthroplasty, Pridie drilling, or microfracture. These procedures are costeffective and clinically useful because patients often have reduced pain and improved joint function, and they are generally considered first-line treatments for focal cartilage defects [3,4,5,6,7]. Autologous chondrocyte implantation (ACI) is the most widely used cell-based surgical procedure for the repair of articular cartilage defects. Third-generation cell-based articular cartilage repair should focus on the use of chondroprogenitor cells and biofunctionalized biomaterials for more extensive and permanent repair
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