A Search for Macroangiopathy in Patients with Latent Diabetes

Abstract

Publisher Summary This chapter discusses macroangiopathy in patients with latent diabetes. In an experiment described in the chapter, the results of the initial diagnostic glucose tolerance tests performed on patients aged 9–17 at diagnosis were shown. The results of the highest glucose tolerance tests obtained in these subjects were presented. Plasma levels of insulin for 15 of these patients who were nonobese were also presented. After administration of glucose, the diabetic group exhibited a significantly subnormal increase in plasma insulin. The mean sum of increments in plasma insulin above fasting levels for all six intervals of the test was significantly less than for control subjects. Results of the glucose tolerance tests performed on patients aged 18–25 years at diagnosis were shown. The mean increase in plasma insulin in 21 of these patients who were nonobese was delayed. 17 of these 21 patients had subnormal levels similar to those of younger patients, while 4 showed responses which, although delayed in reaching peak levels, were greater than the mean response of control subjects.