Abstract
The protective effects of different concentrations of aqueous extract of Rhus coriaria L. fruit (75 and 100μg/ml) and also gallic acid (100μM) as one of its main components were examined against oxidative stress toxicity induced by cumene hydroperoxide (CHP) in isolated rat hepatocytes. Both extract concentrations and gallic acid (100μM) significantly (P<0.05) protected the hepatocyte against all oxidative stress markers including cell lysis, ROS generation, lipid peroxidation, glutathione depletion, mitochondrial membrane potential decrease, lysosomal membrane oxidative damage and cellular proteolysis. Aqueous extracts of Rhus coriaria L. (75 and 100μg/ml) were more effective than gallic acid (100μM) in protecting hepatocytes against CHP induced lipid peroxidation (P<0.05). On the other hand gallic acid (100μM) acted more effective than aqueous extracts of Rhus coriaria L. (75 and 100μg/ml) at preventing hepatocyte membrane lysis (P<0.05). In addition H2O2 scavenging effect of both extract concentrations (75 and 100μg/ml) were determined in hepatocytes and compared with gallic acid (100μM). Gallic acid (100μM) was more effective than aqueous extracts of Rhus coriaria L. (75 and 100μg/ml) at H2O2 scavenging activity (P<0.05).
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