Abstract
AbstractA concise, scalable, and industrially applicable process for the synthesis of the antidepressant agomelatine is described. The process relies on a tandem allylic chlorination–isomerization sequence, on a tetralone‐derived allyl carbinol, as the key transformation. The target compound is obtained in five steps from commercially available 7‐methoxy‐1‐tetralone, in 52.3 % overall yield after final recrystallization.
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