A Sandwich Nanostructure of Gold Nanoparticle Coated Reduced Graphene Oxide for Photoacoustic Imaging-Guided Photothermal Therapy in the Second NIR Window.

Zhihua Wang,Ting Huang,Jibin Song,Xiao Sun,Yudong Wang

doi:10.3389/fbioe.2020.00655

Abstract

We explore a sandwich-type gold nanoparticle coated reduced graphene oxide (rGO-AuNP) as an effective nanotheranostic platform for the second near-infrared (NIR-II) window photoacoustic (PA) imaging-guided photothermal therapy (PTT) in ovarian cancer. The PEG was loaded onto the AuNPs surface to increase the stability of nanostructure. The forming rGO-AuNPs- PEG revealed very strong SERS signal, NIR-II PA signal and high photothermal efficiency against tumor upon 1,061 nm laser irradiation. The prominent performance was attributed to the plasmonic coupling of AuNPs, and the enhanced response of rGO and the plasmonic AuNP. Thus, our study demonstrates that the rGO-AuNP nanocomposite could promise to be a potential photothermal agent and pave the way for the diagnosis and therapy of ovarian cancer in the future.

Highlights

Ovarian cancer has the highest mortality among all gynecological cancers (Kossaï et al, 2018; Gao et al, 2019)
We explore a sandwich-type gold nanoparticle coated reduced graphene oxide as an effective nanotheranostic platform for the second near-infrared (NIR-II) window photoacoustic (PA) imaging-guided photothermal therapy (PTT) in ovarian cancer
PTT utilizes the photothermal effect of photothermal conversion agents that can convert light energy into heat by locally activated upon skin-penetrating NIR radiation (Liu et al, 2019), which raise the temperature of surrounding tissue and trigger the death of cancer cells

Summary

Introduction

Ovarian cancer has the highest mortality among all gynecological cancers (Kossaï et al, 2018; Gao et al, 2019). Tremendous efforts in biomedical research have been devoted to developing more accurate and effective strategies for diagnosis and therapies of ovarian cancer (Nukolova et al, 2011; Romero and Bast, 2012; Liu and Matulonis, 2014; Nick et al, 2015; Grunewald and Ledermann, 2017; Schwartz et al, 2018; Wang et al, 2018). The photoacoustic (PA) imaging-mediated photothermal therapy (PTT) is an emerging treatment, which can potentially improve therapeutic efficacy against cancer (Huang et al, 2014; Chen et al, 2019; Jin et al, 2019; Xu et al, 2019). PTT is a highly efficient and non-invasive

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Conclusion