Abstract
An experimental system for rapid measurement of regional lung deposition of Di-2-ethylhexyl sebacate (DEHS) aerosol particles was established in the present study. The principal goal was to identify the most relevant components of the sampling train and the proper instruments to be employed. After completing the search for an optimal sampling train and instruments, a human subject test was performed. Overall, the sampling train consisted of a mouthpiece, flow meter, and particle counter. The mouthpiece was attached to a Fleisch pneumotachograph. Several TSI condensation particle counters (CPCs), a PC-LabCard and a personal computer were employed to measure and record the counts of test particles at 100 Hz. A cylinder-piston breathing machine was built to generate a series of “standard” breathing patterns. For non-human subject tests, an acrylic tube, 5 cm diameter × 60 cm length, packed with a piece of 100 ppi foam disks was used as a substitute for the human respiratory tract. The optimal sampling train was determined to be a 1TH Fleisch pneumotachograph with a CPC model 3025A because of its short response time and low flow fluctuation. A healthy non-smoking man volunteered to be the subject, and was asked to follow breathing patterns generated by a cylinder-piston breathing machine. The local deposition efficiency was calculated for 1 μm DEHS particles of each 50 cm 3 volumetric region. The deposition data showed a good agreement with previous studies. Compared to the conventional bolus system, the advantage of the rapid measurement system developed in this work is its simplicity, low exposure, and high efficiency.
Highlights
Inhalation is the most important route of entry for atmospheric aerosol
An experimental system for rapid measurement of regional lung deposition of Di-2-ethylhexyl sebacate (DEHS) aerosol particles was established in the present study
The physical factors that result in differences in regional lung deposition are similar to those of particles collecting on a filter
Summary
Inhalation is the most important route of entry for atmospheric aerosol. Further, it is necessary to determine the specific region of particle deposition in the respiratory tract for properly evaluating human health risk. Total deposition measurements estimated the intake dose by comparing the aerosol concentrations in inhaled and exhaled air (Heyder et al, 1973; Heyder et al, 1975; Yu and Diu, 1983; Tu and Knutson, 1984; Brand et al, 2000; Jaques and Kim, 2000; Kim and Jaques, 2004; Montoya et al, 2004; Kim and Jaques, 2005; Löndahl et al, 2006). Local deposition measurements provide detailed information on the longitudinal regional distribution of deposition within the respiratory tract
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