Abstract
What We're Reading| July 01 2022 A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors Author & Article Information Online Issn: 2326-6074 Print Issn: 2326-6066 ©2022 American Association for Cancer Research2022American Association for Cancer Research Cancer Immunol Res (2022) 10 (7): 785. https://doi.org/10.1158/2326-6066.CIR-10-7-WWR Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share MailTo Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record July 1 2022 Citation A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors. Cancer Immunol Res 1 July 2022; 10 (7): 785. https://doi.org/10.1158/2326-6066.CIR-10-7-WWR Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search A new cancer vaccine induces T-cell and NK-cell antitumor immunity (from Brenda Melendez and Rita Serda, via NIH Flickr) Most cancer vaccines being developed boost T-cell responses through immunization with tumor antigens. Badrinath and colleagues report the development and preclinical characterization of a new vaccine that induces the production of antibodies specific for the α3 domain of MHC class I chain-related protein A and B (MICA/B), stress proteins expressed by many cancers. The antibodies prevent proteolytic shedding of MICA/B, leading to enhanced NK-cell cytotoxicity and increased cross presentation of tumor antigens to CD8+ T cells by type 1 conventional dendritic cells (cDC1). The vaccine reduces growth and metastasis of mouse tumors, including MHC class I–deficient tumors resistant to CTLs, highlighting the potential of this vaccine approach to overcome tumor escape from peptide-based cancer vaccines. Badrinath S, …, Wucherpfennig KW. Nature 2022 May 25. DOI:10.1038/s41586–022–04772–4. Cells and their interactions may not... You do not currently have access to this content.
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