A Sampling of Highlights from the Literature

Abstract

What We're Reading| May 03 2022 A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors Author & Article Information Online Issn: 2326-6074 Print Issn: 2326-6066 ©2022 American Association for Cancer Research2022American Association for Cancer Research Cancer Immunol Res (2022) 10 (5): 541. https://doi.org/10.1158/2326-6066.CIR-10-5-WWR Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record May 3 2022 Citation A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors. Cancer Immunol Res 1 May 2022; 10 (5): 541. https://doi.org/10.1158/2326-6066.CIR-10-5-WWR Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search Coinhibitory receptor expression is regulated by a dynamic network of gene regulators (from johnhain via Pixabay) How expression of human T-cell coinhibitory receptors, which are targets of immune checkpoint blockade (ICB) therapy, is regulated is not well understood. Using computational and biological approaches, Sumida et al. show that IFNβ regulates expression of these receptors; expression of PD-1, LAG-3, and TIM-3 is induced, whereas expression of TIGIT is downregulated. These changes are elicited by a dynamic network of gene regulators that includes two mutually antagonistic modules of regulators with opposite temporal kinetics. The identification of new regulators of T-cell coinhibitory receptor expression has the potential to lead to new approaches to enhance ICB therapy for cancer. Sumida TS, …, Hafler DA. Nat Immunol 2022 March 17;23:632–642. Genome-scale screening can identify ways to enhance T cell–based immunotherapy (from TheDigitalArtist via Pixabay) Genome-scale screens can identify potential ways to enhance the effectiveness... You do not currently have access to this content.