A Sampling of Highlights from the Literature

Abstract

What We're Reading| March 01 2023 A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors Author & Article Information Online ISSN: 2326-6074 Print ISSN: 2326-6066 ©2023 American Association for Cancer Research2023American Association for Cancer Research Cancer Immunol Res (2023) 11 (3): 277. https://doi.org/10.1158/2326-6066.CIR-11-3-WWR Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record March 1 2023 Citation A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors. Cancer Immunol Res 1 March 2023; 11 (3): 277. https://doi.org/10.1158/2326-6066.CIR-11-3-WWR Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search Human fibrinogen E domain (from 5-HT2AR via Wikimedia Commons) Incomplete surgical removal of a solid tumor increases a patient's risk for local tumor recurrence. Using xenograft models of incomplete excision of pancreatic ductal adenocarcinoma (PDAC) and triple-negative breast cancer (TNBC), Uslu and colleagues show that intra-operative application of mesothelin-targeted chimeric antigen receptor (CAR) T cells in a fibrin glue–based carrier results in clearance of residual tumor cells and increased survival compared with the same application of the CAR T cells into the tumor cavity in the absence of fibrin gel. The treatment had limited on-target off-tumor toxicity and did not lead to wound healing complications, supporting its clinical evaluation. Uslu U, …, June CH. Sci Adv 2023 January 11;9:eade2526. Neutrophil (from Blausen Medical via Wikimedia Commons) Neutrophils have a complex role in cancer. They often promote tumor growth and metastasis but can exert antitumor activity in certain contexts. Using... You do not currently have access to this content.