A Sampling of Highlights from the Literature

Abstract

What We're Reading| April 03 2023 A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors Author & Article Information Online ISSN: 2326-6074 Print ISSN: 2326-6066 ©2022 American Association for Cancer Research2022American Association for Cancer Research Cancer Immunol Res (2023) 11 (4): 399. https://doi.org/10.1158/2326-6066.CIR-11-4-WWR Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record April 3 2023 Citation A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors. Cancer Immunol Res 1 April 2023; 11 (4): 399. https://doi.org/10.1158/2326-6066.CIR-11-4-WWR Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search Exon–TE splicing junctions are a source of tumor-specific antigens (from Sukhjinder via Pixahive) Emerging evidence indicates that tumor-associated MHC-I–presented peptides can be generated from noncanonical transcripts. Two studies expand the landscape of such transcripts to include transcripts generated by mRNA splicing events between exons and transposable elements (TE). In patients with non–small cell lung cancer, Merlotti et al. identify CD8+ T cells that recognize tumor-specific HLA-I–bound peptides encoded by transcripts generated from exon–TE splicing junctions. Burbage et al. find that immunization with peptides derived from exon–TE splicing junctions slows tumor growth in several mouse tumor models. Together, the data suggest these peptides could be harnessed to develop therapeutic cancer vaccines or TCR-based cell therapies. Merlotti A, …, Amigorena S. Sci Immunol 2023 February 3;8:eabm6359. Burbage M, …, Amigorena S. Sci Immunol 2023 February 3;8:eabm6360. Tuned-up CARs can improve therapeutic efficacy (from Ari Helminen via Flickr) Use of... You do not currently have access to this content.