A Sampling of Highlights from the Literature.

Abstract

What We're Reading| June 02 2023 A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors Author & Article Information Online ISSN: 2326-6074 Print ISSN: 2326-6066 ©2023 American Association for Cancer Research2023American Association for Cancer Research Cancer Immunol Res (2023) 11 (6): 703. https://doi.org/10.1158/2326-6066.CIR-11-6-WWR Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record June 2 2023 Citation A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors. Cancer Immunol Res 1 June 2023; 11 (6): 703. https://doi.org/10.1158/2326-6066.CIR-11-6-WWR Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search TREM2+ mo-macs limit NK-cell recruitment and activation in lung cancer (from NIAID via NIH Flickr) Natural killer (NK) cells have potent antitumorigenic capabilities but are often present at low frequency or are dysfunctional in the tumor microenvironment. Park et al. have identified a reason for this, showing in the KP mouse model of lung cancer that monocyte-derived macrophages (mo-macs) expressing triggering receptor expressed on myeloid cells 2 (TREM2) restrict NK-cell recruitment and activation by limiting IL18 signaling and IL15 production. Targeting TREM2 and activating NK cells with an antibody that stabilizes MIC-A effectively controls tumor growth, highlighting the translational potential of the new study. Park MD, …, Merad M. Nat Immunol 2023 April 20;24:792–801. Number and activity of TRM-like cells influences lung tumor immunity (from Neelima Shah, Edna Cukier man via Flickr) Tissue-resident memory T (TRM) cells provide protection against local infections and can mediate antitumor immunity.... You do not currently have access to this content.