A route for the preparation of [32P]‐sodium monofluorophosphate

Abstract

[32P]-labelled sodium monofluorophosphate (Na2FPO3) was prepared according to a procedure, which is based on melting of a mixture of carrier-added [32P]-phosphoric acid and ammonium bifluoride, both solid. Monofluorophosphate was precipitated as the silver salt from the reaction mixture, then it was converted to the sodium salt by using a cation exchange column in Na+ form. The influence of the molar ratios of the reactants, and the reaction time on the final yield was studied. Powder X-ray diffraction showed a chemical purity of about 98% and absence of NaF in the final product. After a reaction time of 2 hours and a molar ratio of the reactants of 1 : 1, the yield for the reaction was 30% of the initial 32P activity, corresponding to a specific activity of 56 MBq 32P per mmol. An increase in yield is possible by increasing the reaction time, a higher specific activity may be obtained by a decrease of carrier phosphoric acid. The advantages of the procedure developed are the availability of [32P]-phosphoric acid, and the simple preparation of the compound. Copyright © 1999 John Wiley & Sons, Ltd.