Abstract
DNA in the eukaryotic nucleus is coiled onto nucleosomes assembled generally as an octamer of well-studied subunits: H2A, H2B, H3 and H4. Several variants of core histones exist in many organisms, and these presumably have alternative functions. The importance of histones in DNA function has been slowly unraveled over many years, and the metaphor of a histone ‘code’ of various amino acid modifications is now rooted in concepts of epigenetic mechanisms. In shifting the focus towards understanding histone variants, a new study of histone H3.3 reveals another fold in the fabric of histone protein function [1].
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