Abstract
Abstract Zeb2 (also known as Zfhx1b and Sip1) is a DNA-binding multi-zinc-finger transcription factor found to play a significant role in the development of cells both early in neuronal differentiation and in cancer metastasis. By binding dual E2 box enhancer elements, Zeb2 acts primarily as a transcriptional repressor and may inhibit E-protein DNA binding, although it is known to act also as a transcriptional activator. Zeb2 also binds activated Smads, the co-repressor CtBP and the NuRD chromatin remodeling complex but not all of its functions may necessarily depend on each of these interactions. While the closely related family member, dEG1/Zfhx1a/Zeb1, is known to plays an early role in lymphocyte development, the function of Sip1 in T lymphocytes remains unknown. We find that Zeb2 is upregulated in activated T cells and that antigen specific T cells show diminished expansion during an immune response. Zeb2 is selectively expressed and necessary for the development of a subset of terminally differentiated CD8+ T cells. We are currently assessing the interplay between Zeb2 and E-proteins in differentiation of naïve CD8+ T cells to cytotoxic effector cells.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
