Abstract
Publisher Summary The large size and ready identifiability of many molluscan neurons makes them particularly convenient for combined biochemical and electrophysiological studies on individual nerve cells. Recently, a number of laboratories have taken advantage of these favorable properties to investigate the role of intracellular second messengers in neurotransmitter actions and have implicated cyclic AMP (CAMP) in the effects of serotonin (5-HT) on several different molluscan neurons. Author's studies have focused on the identified neuron R15, in the abdominal ganglion of the marine mollusc Aplysia californica . R15 is an endogenous “bursting” neuron; it exhibits a pattern of spontaneous activity comprising bursts of action potentials separated by interburst hyperpolarizations. It has been found that 5-HT causes R15 to hyperpolarize and stop bursting. This hyperpolarization results from an increase in K’ conductance and is mediated by CAMP. This chapter presents biochemical and electrophysiological evidence that protein phosphorylation is involved in the regulation of K’ conductance in neuron R15.
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