A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition

Abstract

Polo-like kinase 4 (PLK4) is canonically known for its cytoplasmic function in centriole duplication. Here we show a noncanonical PLK4 function of regulating the transcription factor SRF's nuclear activity and associated myofibroblast-like cell-type transition. In this context, we have further found that PLK4's phosphorylation and transcription are respectively regulated by PDGF receptor and epigenetic factor BRD4. Furthermore, invivo experiments suggest PLK4 inhibition as a potential approach to mitigating vascular fibrosis.