Abstract
Background The airway epithelium constitutes the first line of defense in the protection against invading pathogens. It acts as a barrier, but it is also is a major source of early released inflammatory mediators, which help shape the inflammatory response. Neuropeptides, such as substance P (SP), have long been considered to be early contributors to the inflammatory response, causing pain hypersensitivity and vasodilation, as well as activation and infiltration of various immune cells. Toll-like receptor 7 (TLR7) is found on the epithelial cells and is known to be activated by viruses. The present study has investigated the relationship between TLR7 activation/expression and SP release/ stimulation.
Highlights
The airway epithelium constitutes the first line of defense in the protection against invading pathogens
It acts as a barrier, but it is is a major source of early released inflammatory mediators, which help shape the inflammatory response
The present study has investigated the relationship between Toll-like receptor 7 (TLR7) activation/expression and substance P (SP) release/ stimulation
Summary
The airway epithelium constitutes the first line of defense in the protection against invading pathogens. A role for neuropeptides in innate immune inflammation of the nose Olivia Larsson1*, Lotta Tengroth1, Yuan Xu1, Susanna Kumlien Georen1, Lars-Olaf Cardell2 From The 10th Symposium of Experimental Rhinology and Immunology of the Nose (SERIN 2015) Stockholm, Sweden.
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