Abstract
A Role for Early Cardiac Function in Cardiac Morphogenesis
Highlights
When James Watson and Francis Crick reported the structure of DNA in 1953, the mechanism of inheritance was instantly apparent
Previous work on yeast from Hiten Madhani and colleagues had shown that one histone variant, called H2A.Z, is found in euchromatin and prevents silent chromatin from spreading into adjacent euchromatic regions
While researchers have characterized some of the mechanisms that deposit canonical histones onto euchromatin, they knew little about the mechanisms that deposit variant histones
Summary
When James Watson and Francis Crick reported the structure of DNA in 1953, the mechanism of inheritance was instantly apparent. Madhani, and colleagues show that protein subunits of SWR1-Com associate with the histone variant H2A.Z. By comparing the gene expression profiles of yeast mutants lacking the H2A.Z-encoding gene with mutants lacking the Swr1p-encoding gene, the authors show that H2A.Z depends on the SWR1-Com protein complex to function. By comparing the gene expression profiles of yeast mutants lacking the H2A.Z-encoding gene with mutants lacking the Swr1p-encoding gene, the authors show that H2A.Z depends on the SWR1-Com protein complex to function Most importantly, they show that SWR1-Com is required in living cells to deposit H2A.Z onto euchromatin. ATM molecule and cannot properly handle DSBs or end is required for the assembly of DNA–ATM–MRN complexes successfully navigate the G1 checkpoint This condition leads to in the presence of fragmented DNA and seems to direct the a host of problems, including abnormal chromosomes, deficient entire damage response.
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