Abstract
ENGRAFTMENT of allogeneic pluripotent hematopoietic stem cells (PHSC) in nonmyeloablated but immunodepleted recipients can produce mixed hematopoietic chimeras in which both host and donor cells coexist and are tolerant of each other. The major mechanism of tolerance in these mixed chimeras is central intrathymic clonal deletion, which is induced and maintained by the immigration of both host and donor marrow-derived cells to the host thymus, ensuring the ongoing central deletion of donorand host-reactive thymocytes. In this study, we addressed the role of different donor-derived hematopoietic cells in the induction and maintenance of mixed hematopoietic chimerism and tolerance in mice receiving non-myeloablative conditioning.
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