Abstract
A role for cGMP-dependent protein kinase II in AMPA receptor trafficking and synaptic plasticity
Highlights
Trafficking of AMPA receptors (AMPARs) underlies the activity-dependent modification of synaptic strength and is regulated by specific interactions of AMPAR subunits with other proteins
CGMP is produced by soluble guanylate cyclase, which is activated by nitric oxide (NO), which is produced by nNOS under the control of the NMDA receptor
We have measured the rate of exogenous GluR1 endocytosis in cultured primary neurons, either the wild type or the S845A or S845D mutants (Figure 1)
Summary
Trafficking of AMPA receptors (AMPARs) underlies the activity-dependent modification of synaptic strength and is regulated by specific interactions of AMPAR subunits with other proteins. Address: 1Department of Biochemistry, NYU Langone Medical Center, New York NY 10016, USA, 2Department of Pathology and Taub Institute, Columbia University, New York, NY, 10032, USA, 3Department of Physiology, NYU Langone Medical Center, New York NY 10012, USA, 4Department of Psychiatry, NYU Langone Medical Center, New York NY 10012, USA, 5Department of Physiological Sciences, Viale A. 6, University of Catania 95125 Catania, Italy and 6Department of Psychiatry, Mt Sinai School of Medicine, New York NY 10029, USA
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