A robust simulation and reconstruction platform of fluorescence molecular tomography

Abstract

Fluorescence molecular tomography (FMT) has many successful applications which has been considered as a promising tomographic method for in vivo small animal imaging. However, most of the reconstruction methods, which are used to solve the forward model and inverse model of FMT, are carried out based on MATLAB or other separate subprogram tools. It is inconvenient to adjust the same parameters in different programs and to apply in multi-modality imaging reconstructions. To solve this problem, a robust simulation and reconstruction platform of FMT is proposed in this paper. The proposed platform is based on Windows, and the development of the platform is based on Visual Studio 2010 with C++, which is used in multi-modality systems of our group. Compared with the traditional divided methods, our proposed platform is more robust in FMT reconstruction and can conveniently integrate with other imaging modalities. Furthermore, more accurate results can be obtained by using our platform which has been shown in this study.