Abstract
A robust circular RNA-based prognostic signature for postoperative recurrence in stage II/III colon cancer.
Highlights
Adjuvant chemotherapy in colon cancer is able to complement curative surgery to reduce the risk of recurrence and death from relapsed or metastatic disease [7,8]
In a recent study published in EMBO Molecular Medicine, entitled “A circular RNA (circRNA) signature predicts postoperative recurrence in stage II/III colon cancer”, Ju et al [15] identified and validated a circRNA-based signature that could improve postoperative prognostic stratification of patients with stage II/III colon cancer
The authors found that 103 circRNAs were differentially expressed in recurrent colon cancer patients as compared to non-recurrent counterparts
Summary
There is still proportions of colon cancer patients that develop recurrence even after radical resection [4]. Long term control of the recurrent colon cancer has been a difficult dilemma to tackle and the clinical outcomes of these patients are poor [5,6]. Adjuvant chemotherapy in colon cancer is able to complement curative surgery to reduce the risk of recurrence and death from relapsed or metastatic disease [7,8].
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