Abstract
BackgroundThe aim of this study was to investigate the correlation between rapid weight gain and early wheezing.MethodsThis study screened 701 infants with lower respiratory tract infection who were no more than 4 months from Jan 1st to Dec 31st in 2018. According to weight-for-age Z-value (WAZ), these infants were divided into the considerably slow weight gain group (group I), the normal weight gain group (group II) and the excessively rapid weight gain group (group III), respectively. The clinical characteristics, weight growth speeds and serum lipid levels were analyzed, and multivariable Logistic model was conducted to select significant variables.ResultsOur results showed that male (OR = 1.841, 95%CI: 1.233–2.751), family wheezing (OR = 5.118, 95%CI: 2.118–12.365), age (OR = 1.273, 95%CI: 1.155–1.403), eczema (OR = 2.769, 95%CI: 1.793–4.275), respiratory syncytial virus (RSV) infection (OR = 1.790, 95%CI: 1.230–2.604), birth weight (OR = 1.746, 95%CI: 1.110–2.746) and total cholesterol (TC) (OR = 1.027, 95%CI: 1.019–1.036) and ΔWAZ (OR = 1.182, 95%CI: 1.022–1.368) were associated with early wheezing. Results indicated that serum TC (P = 0.018) and ΔWAZ (P = 0.023) were positive correlation with wheezing days.ConclusionBesides male, family wheezing, age, eczema, RSV infection, birth weight and TC, the rapid weight growth as a risk factor should be concerned in the early wheezing infants.
Highlights
The aim of this study was to investigate the correlation between rapid weight gain and early wheezing
Besides male, family wheezing, age, eczema, respiratory syncytial virus (RSV) infection, birth weight and total cholesterol (TC), the rapid weight growth as a risk factor should be concerned in the early wheezing infants
The statistical differences among the three groups were shown in birth weight and length, weight and length at admission, family obesity, family wheezing, individual history of hypersensitivity, family hypersensitivity, wheezing, premier wheezing, the length of wheezing (LOW), length of stay (LOS), TC, TG and low density lipoprotein (LDL) (P < 0.05)
Summary
The aim of this study was to investigate the correlation between rapid weight gain and early wheezing. 50% of children suffered from wheezing in infancy and childhood [2], and roughly 26% of 6265 babies had wheezing at least once within 18 months after birth from a prospective study [3]. The previous study has manifested that weight-gain acceleration in early infancy was related to the increased risk of asthma symptoms in preschool children [6]. Several studies have reported that weight gain in infants is a risk factor for wheezing in childhood and even puberty [8,9,10,11,12,13,14]. There are few researches focusing on the relationship between the weight gain speed and wheezing in infants, especially early infantile
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