Abstract
Abnormal Cu(II) ions levels may affect many biological functions, and it is of great importance to detect Cu(II) ions in organisms. Herein, we report a near-infrared (NIR) fluorescent probe EtRh-N-NH2 for the detection of Cu(II). In the probe structure, a rhodamine core was used, and a hydrazine group was employed as the responsive site. Results & Conlusions: EtRh-N-NH2 displayed sensitive, specific and fast response upon Cu(II) with excellent linear relationship between the concentration and fluorescence emission intensity in 0-1 μM range. The releasing EtRh-COOH exhibited 762 nm of emission wavelength with a 75 nm of Stokes shift.
Highlights
The copper element amount in the human body and other biological systems is only trace but essential and indispensable [1,2]
EtRh-N-NH2 was synthesized via a three-step method from 2-(5-(diethylamino)-2hydroxybenzoyl) benzoic acid (Scheme 2)
As depicted in Scheme 3, we proposed the mechanism of the fluorescent turning-on process of the designed probe EtRh-N-NH2
Summary
The copper element amount in the human body and other biological systems is only trace but essential and indispensable [1,2]. There are lots of methods for the detection of copper ions, mainly including fluorescent hybrid nanomaterials [11] and fluorescent chemical sensors [12]. Cu(II) fluorescent chemical sensors are mostly designed and synthesized based on inorganic [rhenium (I), ruthenium (II), iridium (III), zinc (II), and gold (I)] [24] and organic materials [25]. These probes can be classified into two categories based on their mechanism of the fluorescence production [26,27]. The probe reveals its ability to detect various active substances in vitro
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
