Abstract
Rapid viral diagnosis is essential to contain the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) in the community and ensure effective patient management. However, the current gold standard for diagnosis of viral disease depends on the time-consuming molecular technique. Surface plasmon resonance (SPR) phenomenon has been widely applied in the analysis of biomolecular interactions and analytes detection, which is currently being investigated as a quick diagnostic method of numerous viral infections. In this regard, researchers have performed experimental studies dedicated to enhancing the sensitivity and specificity of the SPR sensor performance for utilization in the medical diagnostic field. In this review, we summarized various SPR application including the recent advancements and advantages of different types of SPR-based biosensor such prism-based, localized surface plasmon resonance (LSPR), fiber optic, optical grating, and optical waveguide for the detection of SARS-CoV2. We proposed various technical recommendations to improve the sensitivity, accuracy, time response, and cost-saving means of the SPR sensor. A special focus was set for sensitivity enhancement aspects in terms of the type of prism, nanomaterials, support layer with type and shape of optical fibers for early, swift, and ultra-sensitive detection of viral infection. With the highlighted impacts of SPR application, this review frames the current potential and challenges of SPR in comparison to the current gold standard of viral infection diagnostic strategy.
Highlights
The severe acute respiratory syndrome coronavirus 2 (SARSCoV2) pandemic started in Wuhan, China before spreading globally through international travelers
This review focuses on the recent advancements of different types of Surface plasmon resonance (SPR) sensors such as prism-based, localized surface plasmon resonance (LSPR), and fiber-optic sensors, for the detection
Since the antigen-rapid test kit (Ag-RTK) can detect approximately 300 viral copies, it might be unable to recognize the virus present in the small respiratory droplets circulating in the air
Summary
Surface Plasmon Resonance-Based Biosensor for Early Screening of SARS-CoV2 Infection. Sharifah Norsyahindah Syed Nor Nur Syafiqah Rasanang Salmah Karman Wan Safwani Wan Kamarul Zaman Sulaiman Wadi Harun Hamzah Arof.
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