A Review: Proniosomes as a Novel Drug Delivery System

Abstract

Novel drug delivery system is a novel approach to drug delivery that addresses the limitations of traditional drug delivery systems and are able to deliver drug at the site of action and at predetermined rate which increases therapeutic efficacy, minimize adverse or side effects and increases bioavailability of the drug. Drug delivery system using colloidal particulate carriers such as liposomes and niosomes have distinct advantages over conventional dosage forms. However, remain significant problems like instability in general application of liposomes and niosomes for drug delivery. In recent time, proniosomal and niosomal system have been received a great attention in drug delivery applications as well as in pharmaceutical research. In order to minimize the problems associated with niosome physical stability such as aggregation, fusion and leaking and to provide additional convenience in transportation, distribution, storage and dosing etc, a dry product can be prepared, which is called proniosome. Proniosomes are dry formulation using suitable carrier coated with nonionic surfactants and can be converted into niosomes immediately before use by hydration. These proniosome-derived niosomes are as good as or even better than conventional niosomes. The current review deals with the trends, different aspects and the future perspective in the development of proniosomal drug delivery systems. (1, 2)