Abstract
Rheumatoid arthritis disease, according to its circadian rhythms shows early morning peak symptoms. Sometimes, single unit (ex. larger tablets) and multiple units (ex. granules, pellets) colon targeted drug delivery systems are not always an efficient treatment option. Because single unit larger tablets may suffer from the disadvantages of unintentional disintegration of the formulation due to manufacturing deficiency or GI variation leading to complete dose dumping. Even the multiple unit drug delivery systems such as granules and pellets also have many drawbacks because of their irregular weights, shapes and sizes. Thus, a tight, reproducible in-vitro and in-vivo release profile canÂ’t be achieved. In an attempt to overcome the problems presented by these delivery systems, advanced system such as multiple unit mini-tablets have developed. This is an approach towards achieving critical factors such as better patient compliance and convenience. In this review, a concerted try has made to provide details of different formulation methods used in preparing mini-tablets of lornoxicam and naproxen drugs for colon targeted delivery in chronotherapy. The techniques formulated and evaluated as core-mini-tablets filled pulsincap drug delivery system (using time dependent polymers), matrix-mini-tablets filled capsule drug delivery system (using microsomal enzyme dependent and pH dependent polymers) and coated-mini-tablets filled capsule drug delivery system (using pH dependent polymers). All these methods were successful in targeting Anti-inflammatory drugs at colonic junction. Hence, the mentioned formulation methods can be successfully used in the chronotherapeutic treatment of Rheumatoid arthritis.
Highlights
Drugs have become the order of day for many people across the world
The mentioned formulation methods can be successfully used in the chronotherapeutic treatment of Rheumatoid arthritis
The various research works mentioned in this review, clearly suggests that the time, pH, and microsomal enzyme dependent polymers can be suitable for preparing mini-tablet formulations for colon targeted delivery of Anti-inflammatory drugs
Summary
Drugs have become the order of day for many people across the world. There is hardly anyone who has not taken a medicine in his/her life, but many times the people who take tablets rarely give importance to the timing of its intake. A concerted try has made to summarize the details of different formulation methods used in preparing mini-tablets of lornoxicam and naproxen drugs for colon targeted delivery in chronotherapy. These mini-tablets possess the combined advantages of a single unit larger tablet and multiple unit granules and pellets, but still devoid of the chances of dose dumping, systemic toxicity, variation in formulation behavior and drug release profile due to unit to unit variation and within the unit variation.
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