A review on transition-metal catalyzed C-H bond carbonylation reactions with CO

Abstract

Carbon monoxide can be used as an inexpensive and readily available C1 source, which is also in agreement with atom economy. Carbonylation reactions with CO have been and continue to be a very active area of research. Since the pioneering work of Heck in 1974, carbonylations of aryl halides and pseudohalides with CO have become one of the most common methods for the addition of a carbonyl group to organic molecules. Recently, transition-metal-catalyzed chelation-assisted carbonylation of C-H bonds for the synthesis of carbonyl compounds. The progress in carbonylation chemistry has been achieved in both academic laboratories and industry. Hence, in this paper, we have reviewed the research work of transition-metal-catalyzed C-H bond carbonylation reactions with CO in recent years. We made introductions of C-H bond carbonylation reactions from three main parts: sp C-H, sp2 C-H and sp3 C-H bond. Some reaction mechanisms were described in the paper. These C-H bonds carbonylation reactions provide a simple and effective method for the synthesis of acids, ketones, esters, amides and anhydrides.