Abstract
The transdermal drug delivery system is widely accepted due to its numerous advantages as it is a non-invasive drug administration process with prolonged therapeutic effect, reduced side effects, improved bioavailability, better patient compliance, and easy termination of drug therapy. Non-steroidal anti-inflammatory drugs such as Diclofenac sodium, Lornoxicam, Aceclofenac, Ibuprofen, antihypertensive drugs, for example, Repaglinide, Atenolol, and Antiviral agents such as Stavudine, zidovudine represents the most commonly used medications for the treatment of pain and inflammatory reaction but various side effects can limit their use. Therefore, transdermal delivery of these drugs has advantages of avoiding hepatic first-pass effect, gastric irritation and delivering the drug for an extended period of time at a sustained level. The present article mainly focuses on the work been done on these drugs by formulated and delivered as transdermal patches to decrease the side effects related to the oral delivery.
Highlights
Inflammation Inflammation is a process that occurs after an infection or tissue injury
We provided valuable information regarding the Transdermal drug delivery (TDD) systems, transdermal patches, and their physicochemical parameters
The development of an efficient means of transdermal administration of non-steroidal anti-inflammatory drugs (NSAIDs) may increase local soft tissue and joint concentrations and reduces the side effects associated with oral administration
Summary
Inflammation Inflammation is a process that occurs after an infection or tissue injury. The membranebased transdermal patches for LRX gel have been studied using OA and polypropylene glycol as penetration enhancers to improve the drug delivery across the skin and evaluated the In vivo analgesic and anti-inflammatory activity. ACF is metabolized to a major metabolite, 4’-hydroxy ACF, and various metabolites including 5-hydroxy ACF, 4’- hydroxydiclofenac, diclofenac, and 5-hydroxydiclofenac [63] It has been previously described the use of hydroxyl propyl cellulose in transdermal patches and ophthalmic preparations and ethyl cellulose transdermal delivery systems as well as other dosage forms for controlled release of drugs [64,65,66,67]. The delivery from a non-oral pathway such as the transdermal route may be helpful in maintaining suitable plasma concentration and useful in improving bioavailability and patient compliance and in avoiding side effects [73,74]. The evaluation and formulation of transdermal patch of Ibuprofen have been carried out to prevent this side effect [16]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
