Abstract
Psoriasis is a long-term, autoimmune inflammatory condition characterized by red, scaly plaques that can range from a few patches to total skin coverage. Over the past 60 years, and more recently, the metal-chelating agent ethylenediaminetetraacetic acid (EDTA) has proven increasingly useful in the treatment and understanding of psoriasis and related conditions. This review will analyze the current role and effectiveness of EDTA in clinical and non-clinical studies designed to improve the diagnosis and treatment of psoriasis in patients. Currently, EDTA demonstrates great medical benefit in the treatment of psoriasis as an antioxidant and as an inhibitor of beta-lipoprotein production. EDTA additionally functions well in research applications due to its ability to maintain red blood cell structural integrity. The authors find that the perceived impact of EDTA in the understanding and combating of psoriasis to be greatly underestimated and is therefore in need of increased awareness and attention by healthcare professionals, dermatologists, and clinical researchers.
Highlights
BackgroundPsoriasis is among the most common autoimmune, inflammatory conditions in the world, with adult estimates ranging from as low as 0.91% in the United States to as high as 8.5% in Norway [1]
Psoriasis is a long-term, autoimmune inflammatory condition characterized by red, scaly plaques that can range from a few patches to total skin coverage
The authors find that the perceived impact of ethylenediaminetetraacetic acid (EDTA) in the understanding and combating of psoriasis to be greatly underestimated and is in need of increased awareness and attention by healthcare professionals, dermatologists, and clinical researchers
Summary
Psoriasis is among the most common autoimmune, inflammatory conditions in the world, with adult estimates ranging from as low as 0.91% in the United States to as high as 8.5% in Norway [1]. An increased number or duration of free radicals can override the defense mechanisms present and lead to conditions such as psoriasis This increased attention to EDTA resulted in studies of EDTA used as an antioxidant occurring in more recent years. Due to the fact that psoriasis is an autoimmune disease, patients with the condition often have increased levels of beta lipoproteins, and the use of EDTA as a treatment could help reduce these levels [27]. Based on the chemical therapy articles in the review, the data could suggest that EDTA is a great antioxidant, its role in decreasing the concentration of beta-lipoproteins is what is mainly causing the cessation of psoriasis symptoms in patients
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