A Review on the Hyphenation of Solid Phase Microextraction with Capillary Electrophoresis and Mass Spectrometry

Abstract

Hyphenation of analytical techniques is a promising trend due to their wide applicability. This article explains the hyphenation of solid phase micro-extraction to capillary electrophoresis. Different modes of solid phase microextraction (SPME) are reported to increase sensitivity of the methods. Various advantages and problems that occurred during the hyphenation are highlighted. Besides using this as a tool of separation, solid phase microextraction capillary electrophoresis (SPME-CE) is considered with special emphasis on applications utilizing its hyphenation to mass spectrometry. As SPME offers a high preconcentration factor, its hyphenation with capillary electrophoresis mass spectrometry (CE-MS) is very promising.