Abstract
Myogenesis of muscle tissues is known as a very complex and delicate process including many cellular differentiation and development events in animals. Here, the courses of cellular fate determination and terminal differentiation of muscle cells are systematically elaborated and the genetic regulatory network of muscle genesis is well conceived in animal organic growth and development through literature retrieval. Furthermore, the principal roles of myogenic regulatory factors, Myostatin, fibroblast growth factor, insulin-like growth factor and other muscular regulatory factors interrelated and reported in the myogenesis relevant studies are also reviewed. In addition, the interactions of these muscular specific factors and their possible relevant regulative pathways and interactions among them are included and developed too.
Highlights
In the past 50-60 years, a great progress has been made in the genetic selection of lean meat rate, growth rate and feed efficiency of domesticated animals
With the intersection and development of these research fields of modern genetics and molecular biology and developmental biology, the perceiving and understanding of myogenesis and development of animal muscle tissues gradually enter into the molecular biology level, such as the genetic control of double muscle phenomena in pigs, cattle and sheep and the genetic selection of lean muscle mass in animal development have been related and referred to candidate genes of Myostatin and Insulinlike growth factor II (IGF-II) (Insulin-Like Growth FactorII, firstly reported in cattle and pigs) and CLPG (Callipyge, firstly reported in sheep and goat)in many short reports and/or detailed studies (McMurtry et al, 1997; Andersson and Georges, 2004; Georges, 2007)
Another key transcription factor interacting with basic helix-loop-helix (bHLH) motif containing proteins is the members of MEF2 family including MADS box proteins or MADS domain transcription factors identified during skeletal muscle development (Wilson-Rawls et al, 1999; Dichoso et al, 2000)
Summary
Corresponding Author: Wuyi Liu Faculty of Biological and Food Engineering, Anhui Province Key Laboratory of Environmental Hormone and Reproduction Fuyang Normal University (Zip 236037), Qing He West Road No 100, Fuyang 236037, China Tel: +86-558-2596562 Fax: +86-558-2596561
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