A Review on the Extraction Process and Therapeutic Activity of Curcumin on Diabetes Mellitus and Cancer

Abstract

Abstract: Turmeric or Curcuma Longa is a natural product whose medicinal properties have been widely studied and a wide range of therapeutic effects in various diseases, including neurodegenerative, liver, kidney damage, cancer and diabetes have been linked mainly to its curcuminoid content. In recent decades Diabetes has become an alarming global health problem due to the increasing prevalence of diabetes. The people who suffer from this disease and the consequences for them are devastating. In this review article we review the current basic and clinical evidence on the potential of curcumin / curcuminoids for the treatment of diabetes mainly due to its hypoglycemic, antioxidant and anti-inflammatory properties. Action of curcumin or curcuminoids as a hypoglycemic agent or only as a healing aid improve metabolic profile and improve diabetes-related complications such as diabetes nephropathy and cardiopathy are discussed. Interactions between curcumin and conventional antidiabetic drugs could be investigated in the treatment of diabetes Curcumin has also been shown to be a mediator of chemoresistance and radioresistance. Anticancer effects have been observed in a number of clinical trials, mainly a natural chemopreventive agent in colon and pancreatic cancer, cervical neoplasia and Barrett's metaplasia. Something clinical studies in healthy volunteers have shown low bioavailability of curcumin, calling into question the use of curcumin alone food additive Our clinical experience with curcumin and the antimetabolite gemcitabine in patients with advanced pancreatic cancer resulted in an objective response in less than 10% of patients with a small effect on survival. However, the safety of this combination has been proven. The potent antiproliferative effects of curcumin, which interact with multiple intracellular signaling pathways, may enhance the antitumor effects of gemcitabine. The Preclinical data lead to various, but still few, clinical trials (some ongoing) that demonstrated the potential effectiveness of the drug. this treatment as a chemopreventive or chemotherapeutic agent. This review focuses on clinical evidence including our experience with curcumin as a chemopreventive and therapeutic agent and background results in vitro.