Abstract
It is estimated by the World Health Organization (WHO) that most of the world's population depends on herbal medicine for their health care. Nigella sativa (N. sativa), also known as black-caraway and as “Kalonji,” is a well-known seed all over the world. It is one of the most common medicinal plants worldwide and contains many useful chemical constituents that we can find in its fixed oil, such as thymoquinone, thymohydroquinone, dithymoquinone, thymol, nigellicine, carvacrol, nigellimine, nigellicine, nigellidine, and alpha-hederin. Due to these numerous important ingredients it was found that it affects different areas of our body and has many pharmacological effects as antibacterial, antiviral, anti-inflammatory, and wound healing effect and also for acne vulgaris, skin cancer, pigmentation, and many cosmeceutical applications. Based on the folklore usage of N. sativa seeds and oil, they are used in various systems of food and medicines. The aim of this article is to provide a detailed survey of the literature of cosmeceutical and external applications of N. sativa which is expected to stimulate further studies on this subject.
Highlights
Nigella sativa, which is a member of the Ranunculaceae family [1], can be found all over the world but grows mainly in Eastern Europe, Middle East, and Western Asia [2]
These findings suggest that N. sativa administration will decrease viral load in patients with hepatitis C virus (HCV) and improve oxidative stress, clinical condition, and glycemic control in diabetic patients
Cytotoxicity of N. sativa essential oil was included in the study and the results showed that the oil in low concentrations had no significant cytotoxicity in the murine macrophages
Summary
Nigella sativa (N. sativa), known as black-caraway and as “Kalonji,” is a well-known seed all over the world It is one of the most common medicinal plants worldwide and contains many useful chemical constituents that we can find in its fixed oil, such as thymoquinone, thymohydroquinone, dithymoquinone, thymol, nigellicine, carvacrol, nigellimine, nigellicine, nigellidine, and alpha-hederin. Due to these numerous important ingredients it was found that it affects different areas of our body and has many pharmacological effects as antibacterial, antiviral, anti-inflammatory, and wound healing effect and for acne vulgaris, skin cancer, pigmentation, and many cosmeceutical applications. The aim of this article is to provide a detailed survey of the literature of cosmeceutical and external applications of N. sativa which is expected to stimulate further studies on this subject
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