Abstract
Metal complexes play an essential role in pharmaceutical sciences for their multiple and important activities. Schiff bases are versatile pharmacophores able to form chelating complexes with several metals in different oxidation states. Complexes with Schiff bases are widely described in the literature for their multiple actions and numerous advantages, such as low cost and easy synthesis. They show multiple biological activities, including antimicrobial, antioxidant, antimalarial, antinflammatory and antitumor. Schiff bases may also form complexes with lanthanides and actinides acting as catalysts (e.g., in various synthetic processes) and antitumor agents. This review intends to extend on our previous paper regarding Schiff bases as antitumorals, highlighting the importance, in the field of the anticancer agents, of these tools as ligands of metal complexes.
Highlights
Published: 29 June 2021Schiff bases (R1 R2 C=NR3 ) are interesting organic compounds containing an azomethine (-CH=N-) or an imine (-C=N-) group generally formed by the condensation of active carbonyl groups and amino compounds, in which the nitrogen atom is bonded to an aryl or alkyl group [1]
As well as diarylureas [8,9,10], have been defined as “privileged” ligands in organic synthesis, thanks to their affordability, easy synthesis and different biological activities and ability to form complexes with almost all metals [11,12,13]. They may form complexes with transition metals, platinum group metals (PGM) [14], lanthanides [15,16], and actinides [17,18] and many of them have been extensively described in the literature [19,20]
Metal complexes bearing in the structure a Schiff base are known for their numerous applications and biological activities including antimicrobial [21], antioxidant [22], antitumor [23], antinflammatory [24], and Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations
Summary
Alessia Catalano 1, * , Maria Stefania Sinicropi 2 , Domenico Iacopetta 2, * , Jessica Ceramella 2 , Annaluisa Mariconda 3 , Camillo Rosano 4 , Elisabetta Scali 5 , Carmela Saturnino 3,6 and Pasquale Longo 7. Metal Complexes with Schiff Bases as Antiproliferative Agents.
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