Abstract
Historically, medications that caused unconsciousness, haemorrhoidal, germicidal, and purgative effects were administered the rectal route as suppository injections. The majority of medicinal drugs on the market today are designed to be administered rectal in order to increase their bioavailability and achieve the necessary therapeutic blood concentration. Historically, only locally acting medications, such as steroids, prostaglandins, spermicidal, antifungal, antibacterial, and antiviral, were allowed during vaginal birth. The capacity to avoid first-pass hepatic processing, accessibility, a healthy blood supply, and permeability to big molecular weight medications, such as peptides and proteins, are the main benefits of this route. Vaginal medicine delivery devices that are frequently utilised include suppositories, creams, gels, pills, and vaginal rings. This message is intended to give the reader an overview of the developments in the area of vaginal medication delivery.
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