A Review on Solid Dispersion and Carriers Used Therein for Solubility Enhancement of Poorly Water Soluble Drugs

Avinash Ramrao Tekade,Jyoti Narayan Yadav

doi:10.34172/apb.2020.044

Avinash Ramrao Tekade, Jyoti Narayan Yadav

Open Access

https://doi.org/10.34172/apb.2020.044

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Abstract

A large number of hydrophilic and hydrophobic carriers in pharmaceutical excipients are available today which are used for formulation of solid dispersions. Depending on nature of carriers the immediate release solid dispersions and/or controlled release solid dispersions can be formulated. Initially crystalline carriers were used which are transformed into amorphous solid dispersions with enhanced properties. The carriers used previously were mostly synthetic one. Recent trend towards the use of natural carriers have replaced the use of synthetic carriers. This review is the overview of various synthetic, natural, semisynthetic, modified natural hydrophilic carriers used for formulation of solid dispersions.

Highlights

Absorption of drug and its therapeutic effectiveness get affected by solubility which is a significant physicochemical factor
A large number of hydrophilic and hydrophobic carriers in pharmaceutical excipients are available today which are used for formulation of solid dispersions
The aim of this article is to update on information regarding hydrophilic carriers used in solubility enhancement by using various solid dispersion methods

Summary

Introduction

Absorption of drug and its therapeutic effectiveness get affected by solubility which is a significant physicochemical factor. Poor aqueous solubility can leads to failure in formulation development process. The main reason behind inadequate bioavailability of drug is its low dissolution rate and low solubility in aqueous medium.[1] A large number of hydrophilic carriers are explored today which have shown significant results for solubility enhancement. Most of the drug substances were innovated but the venture to improve the solubility and dissolution of hydrophobic drug substances remain one of the trickiest tasks in drug development. Dissolution of drug in aqueous medium like gastric fluid is important to get better absorption and bioavailability for orally administered drug. To progress bioavailability of poorly water soluble compounds like biopharmaceutical classification system class II and IV drugs, polymer matrix of various origin can be used.

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