Abstract
The Scianna blood group system consists of seven antigens expressed on erythrocyte membrane-associated protein (ERMAP) which is encoded by the gene present on the short arm of chromosome 1 at 1p36.2-p22.1 locus which is close to but distinct from Rh locus. The 475 amino acid ERMAP glycoprotein belongs to immunoglobulin superfamily containing a single IgSF domain. It is highly expressed in erythroid tissues. The antibodies of Scianna blood group are clinically less significant. ERMAP glycoprotein is thought to be involved in cell adhesion/receptor, immune recognition and signal transduction.
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