Abstract
The mammalian branch of the Transient Receptor Potential (TRP) superfamily of cation channels consists of 28 members. They can be subdivided in six main subfamilies: the TRPC (‘Canonical’), TRPV (‘Vanilloid’), TRPM (‘Melastatin’), TRPP (‘Polycystin’), TRPML (‘Mucolipin’) and the TRPA (‘Ankyrin’) group. The TRPV subfamily comprises channels that are critically involved in nociception and thermo-sensing (TRPV1, TRPV2, TRPV3, TRPV4) as well as highly Ca2+ selective channels involved in Ca2+ absorption/ reabsorption in mammals (TRPV5, TRPV6). In this review we summarize fundamental physiological properties of all TRPV members in the light of various cellular functions of these channels and their significance in the various diseases.
Highlights
The Transient receptor potential vanilloid (TRPV) family of ligand gated ion channels represents a group of non-selective cation channels
In the rat model of irritable bowel syndrome, during the neonatal period it has been found that TRPV1 antagonists leads to prevent the development of visceral hypersensitivity initiated by acetic acid treatment (Winston, Shenoy et al 2007; Keszthelyi, Troost et al 2013)
They confirmed that ACBD3 (Acyl CoA binding domain protein) and A kinase adapter protein (AKAP)-like protein having a direct interaction with the TRPV2 channels
Summary
Department of Pharmaceutical Sciences 1,2Associate Professor, 3Assitant Professor DDM College of Pharmacy, Una, Himachal Pradesh, India, Pincode-177213 Article Info: Received 5 February. 2021; Accepted 5 March 2021 DOI: https://doi.org/10.32553/jbpr.v10i2.857 Corresponding author: Kiran Thakur Conflict of interest statement: No conflict of interest
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
