A Review on Polymer and Lipid-Based Nanocarriers and Its Application to Nano-Pharmaceutical and Food-Based Systems.

Hongyun Lu,Shengliang Zhang,Jinling Wang,Qihe Chen

doi:10.3389/fnut.2021.783831

Hongyun Lu, Shengliang Zhang + Show 2 more

Open Access

https://doi.org/10.3389/fnut.2021.783831

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Abstract

Recently, owing to well-controlled release, enhanced distribution and increased permeability, nanocarriers used for alternative drug and food-delivery strategies have received increasingly attentions. Nanocarriers have attracted a large amount of interest as potential carriers of various bioactive molecules for multiple applications. Drug and food-based delivery via polymeric-based nanocarriers and lipid-based nanocarriers has been widely investigated. Nanocarriers, especially liposomes, are more and more widely used in the area of novel nano-pharmaceutical or food-based design. Herein, we aimed to discuss the recent advancement of different surface-engineered nanocarriers type, along with cutting-edge applications for food and nanomedicine and highlight the alternative of phytochemical as nanocarrier. Additionally, safety concern of nanocarriers was also highlighted.

Highlights

There have been major breakthroughs in the field of nanotechnology, especially in the fields of materials science, electronics, photonics, supramolecular assembly, drug delivery, agriculture and food industries
The results showed that such modified chitosan nano-microcapsules had a high encapsulation rate on seaweed oil and could avoid the effects of ultraviolet light and heat on the quality of seaweed oil
The results showed that citrus essential oil nanocapsules could significantly prolong the shelf life of marine fish and have a broad prospect of application in the field of marine product preservation

Summary

Introduction

There have been major breakthroughs in the field of nanotechnology, especially in the fields of materials science, electronics, photonics, supramolecular assembly, drug delivery, agriculture and food industries. Nanomedicine is being taken as a promising way in drug delivery and diagnostics. Due to improved penetration and delivery of drugs into specific regions of skin, nanocarriers taken as alternative drug-delivery strategies have gained increasingly interest. A large number of studies have focused on nanocarriers as effective diagnostic or therapeutic tools for serious diseases, such as cancer, infectious or neurodegenerative diseases [4, 5]. Nanocarriers could improve the solubility of hydrophobic nutraceuticals more efficiently, and they have almost no effect on the appearance of final food products, such as, drinks and beverages [6]. Research has highlighted the complexity of the physicochemical and biochemical processes involved in the bioavailability of biocomponents, such as release, absorption, distribution, metabolism, and excretion, which contribute to increase the bioavailability of bioactive compounds used in food fortification [7]

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