A Review on Nanocrystals Drug Delivery System

Abstract

With the advent of modern technologies, a large number of drugs have been discovered which have a better efficiency but their clinical application is restricted due to poor water solubility. Nearly 40% of the drugs in the pipeline and around 60% of compounds coming directly from synthesis have poor solubility. Poor water solubility has become a leading challenge for the formulation of these compounds. Poor solubility is generally associated with poor bioavailability. Nanocrystals have the potential to overcome this issue. Change of materials into the nanodimension dramatically changes its physical properties which were used in pharmaceutics to develop a new innovative formulation principle for poorly soluble drugs: the drug nanocrystals. Drug nanocrystals are crystals with a size in the nanometer range (mean diameter < 1000 nm). The present article describe the details about the drug nanocrystals. Drug nanocrystals consist of poorly soluble drug without matrix material means carrier free drug delivery system. The review article includes method of preparation, properties, advantages of nanocrystals and application of nanocrystals through all routes of administration.