A Review On Mucormycosis In A Clinical Microbiological Dilemma

Abstract

Mucormycetes are a type of rare but opportunistic fungal pathogen that can cause serious and sometimes fatal fungal infections, including mucormycosis. During the second wave of the catastrophic COVID-19 epidemic, which occurred in India between April and June of 2021, mucormycosis, also known as black fungus, caused extreme disruption due to its abrupt and destructive surge that resulted in up to 50% mortality rate.People with diabetes who have recovered from COVID-19 infection have been found to be more susceptible to mucormycosis. However, in order to understand the pathophysiology and pathological components of this lethal infection and to find appropriate prophylactic and therapeutic measures, it is necessary to examine the exact cause and mechanism(s) driving its rise. The indiscriminate use of zinc, steroids, and antibiotics as self-medication during the COVID-19 pandemic is thought to have contributed to gut microbiota dysbiosis, which has been linked to immune suppression and increased susceptibility to mycotic diseases in the risk group. Given this scenarios, this timely article makes an effort to consider and talk about a few probable contributing elements and mechanisms that might aid in understanding and explaining the mystery surrounding the unexpected, sharp, and lethal spike in mucormycosis infections during the second wave of the COVID-19 pandemic.