Abstract
The nephron, which is the kidney's fundamental functional unit, is made up of a variety of cell types grouped into a nephron. Any stimulus that cause these cells to die can result in kidney damage and leads to nephrotoxicity. Renal failure can be caused by either intrinsic or extrinsic factors. Diabetes, cardiovascular disease, sepsis, obesity, and liver and lung failure are examples of extrinsic causes. Renal fibrosis, polycystic kidney disease, Glomerular nephritis, stones and tubular cell death are all intrinsic causes. To date, multiple strategies have been effective in developing various screening tools to imitate human diseases, including kidney damage (nephrotoxicity).Such models have been crucial in the research of mechanism, pathogenesis, and, most critically, the identification of new therapeutic compounds derived from natural products for the treatment of renal disease patients. We review key information on various in-vivo as well as in-vitro screening models used to estimate drugs nephroprotective effect.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: International Journal of Advanced Research in Science, Communication and Technology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.