A Review on Expedient Assets of Polymers Employed in Novel Topical Formulation for Successful Treatment of Arthritis

Abstract

Background: Rheumatoid arthritis (RA) is an autoimmune ailment where the body's defense system is violated by damaging its joints. In RA treatment strategies, attempts have been made for oral, topical, and parenteral formulations with different drugs, but none of the formulations could be regarded as the perfect dosage form. In the current review, the meticulous discussion has been made on the suitability of novel topical formulations in the treatment of RA. Moreover, the emphasis has been made on activities of biodegradable polymers such as hyaluronic acid, lecithin, pluronic acid, chitosan, human serum albumin (HSA), and polylactide glycolic acid (PLGA) as well as their role in the management of RA. Objective: The study aimed to apprehend the role of polymeric materials in developing an ideal topical drug delivery system that can bestow targeted delivery, enhanced penetration of drugs, improved stability of the formulation, and improved PKPD profile of the drugs. : These polymers possess twofold functions, primarily by increasing skin penetration and secondarily by improving joint mobility and cartilage regeneration. Furthermore, biocompatibility and biodegradability are features that increase the use of the aforementioned polymers. Results: The significant role of all the polymers in improving the conditions of bones and joints suffering from rheumatoid arthritis has been demonstrated by various studies.